Ageing Phenotype Observation—Data Type 1 : OB_005484
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Saccharomyces cerevisiae | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Deletion abolished the lifespan extension conferred by calorie restriction. Overexpression extended mean lifespan by 20%, did not further extend lifespan under CR, and was not dependent on the Sir2 family. Overexpression also extended cell survival during prolonged culture at stationary phase. | ||||
PubMed | : | 17200108 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_005484 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Easlon E, Tsang F, Dilova I, Wang C, Lu SP, Skinner C, Lin SJ:
The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension.
J Biol Chem. 2007; 282: 6161-71.
PubMed (ID: 17200108), PubMed Central (ID: PMC2440684), doi:10.1074/jbc.M607661200
MeSH Terms: Dihydrolipoyllysine-Residue Acetyltransferase/physiology; Life Expectancy; Yeasts/cytology; Yeasts/enzymology