Ageing Phenotype Observation—Data Type 1 : OB_005504
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Caenorhabditis elegans | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | A loss-of-function mutation in lin-14 extended lifespan by 31% while a gain-of-function mutation decreased lifespan. The life-extending effects were dependent on daf-16 and hsf-1. Also, lin-14 is a target of lin-4. | ||||
PubMed | : | 16373574 | ||||
Observation Stable ID | : | OB_005504 | ||||
Source | : | GenAge | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Boehm M, Slack F:
A developmental timing microRNA and its target regulate life span in C. elegans.
Science. 2005; 310: 1954-7.
PubMed (ID: 16373574), doi:10.1126/science.1115596
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Longevity/physiology; MicroRNAs/physiology; Nuclear Proteins/physiology; RNA, Helminth/physiology; Repressor Proteins/physiology