Ageing Phenotype Observation—Data Type 1 : OB_005541
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Conditional knockouts with reduced expression develop normally but lifespan is greatly reduced with most animals living 10-12 weeks accompanied by deficiencies in the proliferative cell compartments of several tissues and increased cancer incidence. | ||||
PubMed | : | 17717065 | ||||
Observation Stable ID | : | OB_005541 | ||||
Source | : | GenAge | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Pruitt SC, Bailey KJ, Freeland A:
Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer.
Stem Cells. 2007; 25: 3121-32.
PubMed (ID: 17717065), doi:10.1634/stemcells.2007-0483
MeSH Terms: Cell Cycle Proteins/genetics; Gene Expression Regulation, Neoplastic/physiology; Lymphoma/genetics; Lymphoma/pathology; Nuclear Proteins/deficiency; Nuclear Proteins/genetics; Stem Cells/metabolism; Stem Cells/pathology