Ageing Phenotype Observation—Data Type 1 : OB_005559
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Although grossly normal at birth, knockout mice display multiple deficiencies with age including hypersensitivity to autoimmune disease, higher oxidative metabolism, resistance to weight-gain, and signs of early ageing such as osteoporosis, decreased muscle mass, and depletion of adult stem cells. Interestingly, Mgat5-/-Pten+/- and Mgat5+/-Pten+/- mutant mice showed a small but significant increase in lifespan when compared to Pten+/- mice, accompanied by an apparent delay in the inevitable development of cancer in Pten+/- mice. | ||||
PubMed | : | 17483135 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_005559 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Cheung P, Pawling J, Partridge EA, Sukhu B, Grynpas M, Dennis JW:
Metabolic homeostasis and tissue renewal are dependent on beta1,6GlcNAc-branched N-glycans.
Glycobiology. 2007; 17: 828-37.
PubMed (ID: 17483135), doi:10.1093/glycob/cwm048
MeSH Terms: N-Acetylglucosaminyltransferases/metabolism; Polysaccharides/metabolism