Ageing Phenotype Observation—Data Type 1 : OB_005612
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Knockout mice develop severe obesity, dyslipidemia, fatty liver disease, increased levels of DNA damage in the mtDNA, and have a tendency to develop hyperinsulinemia. | ||||
PubMed | : | 16446448 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_005612 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Vartanian V, Lowell B, Minko IG, Wood TG, Ceci JD, George S, Ballinger SW, Corless CL, McCullough AK, Lloyd RS:
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Proc Natl Acad Sci USA. 2006; 103: 1864-9.
PubMed (ID: 16446448), PubMed Central (ID: PMC1413631), doi:10.1073/pnas.0507444103
MeSH Terms: DNA Glycosylases/deficiency; DNA Glycosylases/metabolism; Gene Deletion; Metabolic Syndrome X/genetics; Metabolic Syndrome X/metabolism