Ageing Phenotype Observation—Data Type 1 : OB_005660
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Brca1 heterozygotes appear to have a shortened life span with 70% tumor incidence. Lymphoma, but not ovarian and mammary gland tumors, occurs commonly in these mice. After a whole-body exposure to ionizing radiation, Brca1 heterozygous mice have a 3–5-fold higher incidence specific to ovarian tumors, but not lymphoma, when compared with the Brca1+/+ mice. | ||||
PubMed | : | 17420720 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_005660 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Jeng YM, Cai-Ng S, Li A, Furuta S, Chew H, Chen PL, Lee EY, Lee WH:
Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.
Oncogene. 2007; 26: 6160-6.
PubMed (ID: 17420720), doi:10.1038/sj.onc.1210451
MeSH Terms: BRCA1 Protein/genetics; Genetic Predisposition to Disease; Heterozygote Detection; Longevity/genetics; Neoplasms, Radiation-Induced/genetics; Ovarian Neoplasms/genetics