Ageing Phenotype Observation—Data Type 1 : OB_005664
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Caenorhabditis elegans | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Gene inactivation of nhx-2 by RNAi led to a loss of fat stores in the intestine and a 40% increase in longevity while double RNAi of nhx-2 and opt-2 led to 10-20% increase in longevity | ||||
PubMed | : | 12939266 | ||||
Observation Stable ID | : | OB_005664 | ||||
Source | : | GenAge | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Nehrke K:
A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span.
J Biol Chem. 2003; 278: 44657-66.
PubMed (ID: 12939266), doi:10.1074/jbc.M307351200
MeSH Terms: Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Sodium-Hydrogen Antiporter/physiology