Ageing Phenotype Observation—Data Type 1 : OB_005688
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Caenorhabditis elegans | ||||
Gene | : |
|
||||
Other Ageing Factor | : | |||||
Description | : | RNA interference slightly shortens lifespan and suppresses life-extension by sir-2.1 overexpression but not by daf-2 mutants. Overexpression extends lifespan by 30%, but is suppressed by RNA interference of daf-16. | ||||
PubMed | : | 16860373 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_005688 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Wang Y, Oh SW, Deplancke B, Luo J, Walhout AJ, Tissenbaum HA:
C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.
Mech Ageing Dev. 2006; 127: 741-7.
PubMed (ID: 16860373), doi:10.1016/j.mad.2006.05.005
MeSH Terms: 14-3-3 Proteins/physiology; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans Proteins/physiology; Caenorhabditis elegans/physiology; Sirtuins/metabolism; Transcription Factors/metabolism