Ageing Phenotype Observation—Data Type 1 : OB_005696
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | ||||
Gene | : |
|
||||
Other Ageing Factor | : | |||||
Description | : | Par4-null mice are prone to develop tumours, both spontaneously and on carcinogenic treatment. The endometrium and prostate of Par4-null mice were particularly sensitive to the development of proliferative lesions. Most (80%) Par4-null females presented endometrial hyperplasia by 9 months of age, and a significant proportion (36%) developed endometrial adenocarcinomas after 1 year of age. Similarly, Par4- null males showed a high incidence of prostate hyperplasia and prostatic intraepithelial neoplasias, and were extraordinarily sensitive to testosterone-induced prostate hyperplasia. 25% reduction in mean LS was observed compared to WT and 20% reduction in MLS. Heterozygote KOLS did not differ significantly from the WT. | ||||
PubMed | : | 15877079 | ||||
Observation Stable ID | : | OB_005696 | ||||
Source | : | GenAge | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- García-Cao I, Duran A, Collado M, Carrascosa MJ, Martín-Caballero J, Flores JM, Diaz-Meco MT, Moscat J, Serrano M:
Tumour-suppression activity of the proapoptotic regulator Par4.
EMBO Rep. 2005; 6: 577-83.
PubMed (ID: 15877079), PubMed Central (ID: PMC1369092), doi:10.1038/sj.embor.7400421
MeSH Terms: Apoptosis/physiology; Endometrial Neoplasms/metabolism; Phenotype; Prostatic Neoplasms/metabolism; Proteins/metabolism; Receptors, Thrombin/metabolism; Urinary Bladder Neoplasms/metabolism