Ageing Phenotype Observation—Data Type 1 : OB_005700
Last modified: Dec 09, 2014. Release 1 • Page created: May 19, 2024
Summary
Species | : | Mus musculus | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Overexpression in skeletal muscle results in an increased number of mitochondria and extended lifespan. Transgenic mice ate 60% more than controls but had half the body weight and 10% of the body fat. | ||||
PubMed | : | 17716967 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_005700 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW:
Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse.
J Biol Chem. 2007; 282: 32844-55.
PubMed (ID: 17716967), doi:10.1074/jbc.M706127200
MeSH Terms: Cytosol/enzymology; Energy Metabolism; Gene Expression Regulation, Enzymologic; Muscle, Skeletal/enzymology; Phosphoenolpyruvate Carboxykinase (GTP)/metabolism