Ageing Phenotype Observation—Data Type 2 : OB_005875
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Saccharomyces cerevisiae | ||||||||||||||
Strain | : | |||||||||||||||
Gene | : |
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Compound | : | |||||||||||||||
Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | increased | ||||||||||||||
Change | : | |||||||||||||||
Observed Lifespan | : | |||||||||||||||
Reference Lifespan | : | |||||||||||||||
Lifespan Unit | : | |||||||||||||||
Measure | : | unknown | ||||||||||||||
Temperature | : | |||||||||||||||
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Sex/Mating Type | : | |||||||||||||||
Description | : | The deletion of SCH9, which encodes for a serine threonine kinase, triples the mean life span and increases resistance to oxidative and thermal stress. Mutations that decrease the activity of the Ras/Cyr1/PKA pathway also extend longevity and increase stress resistance by activating transcription factors Msn2/Msn4 and the mitochondrial antioxidant enzyme superoxide dismutase (Sod2). | ||||||||||||||
Observation Stable ID | : | OB_005875 | ||||||||||||||
Source | : | GenAge | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Longo VD:
The Ras and Sch9 pathways regulate stress resistance and longevity.
Exp Gerontol. 2003; 38: 807-11.
PubMed (ID: 12855292)
MeSH Terms: Genes, ras; Protein Kinases/metabolism; Saccharomyces cerevisiae Proteins; Signal Transduction/physiology; Yeasts/physiology