Ageing Phenotype Observation—Data Type 2 : OB_005930
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Mus musculus | ||||||||||||||
Strain | : | |||||||||||||||
Gene | : |
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Compound | : | |||||||||||||||
Other Ageing Factor | : | |||||||||||||||
Significant Lifespan Effect | : | decreased | ||||||||||||||
Change | : | |||||||||||||||
Observed Lifespan | : | |||||||||||||||
Reference Lifespan | : | |||||||||||||||
Lifespan Unit | : | |||||||||||||||
Measure | : | unknown | ||||||||||||||
Temperature | : | |||||||||||||||
Temperature Unit | : | |||||||||||||||
Sex/Mating Type | : | |||||||||||||||
Description | : | Knockout mice develop signs of premature ageing including a short lifespan. | ||||||||||||||
Observation Stable ID | : | OB_005930 | ||||||||||||||
Source | : | GenAge | ||||||||||||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW:
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
Cell. 2006; 124: 315-29.
PubMed (ID: 16439206), doi:10.1016/j.cell.2005.11.044
MeSH Terms: Aging/metabolism; Genetic Diseases, Inborn/genetics; Genomic Instability; Sirtuins/genetics; Sirtuins/physiology