Ageing Phenotype Observation—Data Type 1 : OB_006291
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Mus musculus | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | Lifespan was extended for both sexes of the Cisd2 TG mice (gain-of-function mutation) without any statistically significant sex difference. In addition, when the Cisd2 TG mice were compared to WT mice, there was no obvious phenotypic effect on body weight or body temperature, or on the measured metabolic indices, including intake of food and water and generation of urine and stool. Aging appeared to be delayed in skin (measured by hair greying and mice's capacity to repel water), muscle and neurons. Mouse mutants also displayed protection of mitochondria from age-associated damage, and reduction of the age-associated decline in mitochondrial function and whole-body energy metabolism. | ||||
PubMed | : | 22661501 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_006291 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Wu CY, Chen YF, Wang CH, Kao CH, Zhuang HW, Chen CC, Chen LK, Kirby R, Wei YH, Tsai SF, Tsai TF:
A persistent level of Cisd2 extends healthy lifespan and delays aging in mice.
Hum Mol Genet. 2012; 21: 3956-68.
PubMed (ID: 22661501), doi:10.1093/hmg/dds210
MeSH Terms: Carrier Proteins/genetics; Longevity/genetics; Nerve Tissue Proteins/genetics