Ageing Phenotype Observation—Data Type 1 : OB_006595
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Caenorhabditis elegans | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | sod-2 mutants are long-lived (maximum lifespan increased by 30%) despite a significant increase in oxidatively damaged proteins. The lifespan of sod1, sod3, sod4 and sod5 mutants was not affected. Examination of worm lifespan revealed that sod-1; sod-3; sod-5 mutant worms live as long as wild-type worms while both sod-2; sod-3; sod-5 and sod-1; sod-2; sod- 4 mutant worms live significantly longer than wild-type (maximum lifespan increased by 30%). | ||||
PubMed | : | 19197346 | ||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_006595 | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Van Raamsdonk JM, Hekimi S:
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.
PLoS Genet. 2009; 5: e1000361.
PubMed (ID: 19197346), PubMed Central (ID: PMC2628729), doi:10.1371/journal.pgen.1000361
MeSH Terms: Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans/enzymology; Longevity/genetics; Mitochondria/enzymology; Sequence Deletion; Superoxide Dismutase/genetics