Ageing Phenotype Observation—Data Type 1 : OB_008031
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Caenorhabditis elegans | ||||
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Other Ageing Factor | : |
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Description | : | rheb-1 RNAi extends lifespan by mimicking the DR effect. Under AL condition, rheb-1 RNAi extends lifespan by 19.1% and the longevity-promoting effects of two DR regimens sDR and intermittent fasting are abolished [ 19079239]. Knockdown of rheb-1 by RNAi only during the adulthood increases mean, median and 75th %ile lifespan by 18-25, 25 and 23-24%, respectively, but failed so in skn-1 or daf-16 mutant (with and without FUdR). Knockdown of rheb-1 dramatically enhances stress tolerance in an skn-1, but not daf-16-dependent manner [ 22560223]. | ||||
PubMed | : | 19079239 | ||||
Observation Stable ID | : | OB_008031 | ||||
Source | : | GenDR | ||||
Download | : | XML |
References
MeSH Terms: Only a subset of the Medical Subject Headings terms is shown: the Major Topics MeSH terms. They describe one of the main topics discussed in the article denoted by an asterisk on the MeSH term or MeSH/Subheading combination on the PubMed page. MeSH terms that belong to the Ageing MeSH are highlighted in green.
- Honjoh S, Yamamoto T, Uno M, Nishida E:
Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.
Nature. 2009; 457: 726-30.
PubMed (ID: 19079239), doi:10.1038/nature07583
MeSH Terms: Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans/metabolism; Fasting/physiology; Longevity/physiology; Monomeric GTP-Binding Proteins/metabolism; Signal Transduction