Ageing Phenotype Observation—Data Type 1 : OB_009662
Last modified: Dec 09, 2014. Release 1 • Page created: Jun 02, 2024
Summary
Species | : | Homo sapiens | ||||
Gene | : |
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Other Ageing Factor | : | |||||
Description | : | The KL gene encodes two proteins: one membrane protein and one secreted transcript that acts as a circulating hormone. Mice mutant for KL show multiple signs of accelerated ageing [0020]. In contrast, overexpression of KL in mice increases lifespan by 20-30%, perhaps through a repression of intracellular INS/IGF1 signals [1485]. KL alleles have also been implicated in human longevity and age-related diseases [0146]. Even though its exact functions remain a mystery, KL may be involved in calcium metabolism and in a vitamin D endocrine system. Premature ageing phenotypes in mice mutant for KL are largely rescued by keeping the animals on a vitamin-D-deficient diet [0245]. KL might also exert its actions through FGF23 [1851]. It is plausible that KL plays some role in human ageing but more work is necessary to confirm this notion and elucidate the mechanisms involved. | ||||
PubMed | : | |||||
Source | : | GenAge | ||||
Observation Stable ID | : | OB_009662 | ||||
Download | : | XML |
References
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