Release 1 - Aug 15, 2014

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Observations List

NOTE:

We distinguish between different types of ageing relevance evidence. Experimental studies on ageing factors result in observations with experimental ageing relevance evidence (1). According to our definition of ageing factors a comparison of two situations, with and without the action of the ageing factor, is required. Almost all data in AgeFactDB is of this type. There are however also a few lifespan data for populations or species included that are certainly relevant to ageing with a slightly different meaning of the term ageing relevance, however. But in this case there is no intervention study and therefore these data cannot be assigned to an ageing factor (2). Furthermore, there are experimental studies where no significant effect of an assumed ageing factor was found (3). And finally there are genes included that are homologous to known ageing-relevant genes for which there is no experimental evidence. They are considered as putative ageing-relevant genes with computational evidence (4).
Order of importance:

  1. yes (Experimental Analysis)
  2. yes, but no ageing factor assigned (Experimental Analysis)
  3. no (Experimental Analysis)
  4. putative (Computational Analysis)
The color indicating the ageing relevance type of an observation may differ from the corresponding color for the ageing factor related to this observation. The reason is that for ageing factors associated with more than one observation, the most important observation color is chosen as ageing factor color. This is always the color with the lowest number in the order given above.

Ageing phenotype observations are considered as experimental analysis. They confirm or reject the ageing relevance for particular ageing factor(s). For genes that are homologous to known ageing-relevant genes there is thus far no experimental evidence. They are considered as candidate genes.
Due to the different data structures of ageing phenotype observation data integrated from other databases we subdivide these observations into type 1 and 2. Observations of type 1 contain the phenotype data mostly unseparated within a single description. Observations of type 2 contain lifespan data in a more structured form (e.g.: separated into lifespan effect, lifespan change, lifespan value). Currently there might be an overlap between the observations of type 1 and 2 from the same source, namely GenAge. But we are working on a reduction of this overlap.

Ageing Relevance:
1 ... 100 [next icon]
# Observation Stable ID Observation Type Species Gene Compound Other Ageing Factor Description Source Additional Source
1 OB_000001 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1000) [PubMed icon] 19372390
2 OB_000002 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1001) [PubMed icon] 19372390
3 OB_000003 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1002) [PubMed icon] 19372390
4 OB_000004 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1003) [PubMed icon] 19372390
5 OB_000005 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1004) [PubMed icon] 19372390
6 OB_000006 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1005) [PubMed icon] 19372390
7 OB_000007 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1006) [PubMed icon] 19372390
8 OB_000008 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1007) [PubMed icon] 19372390
9 OB_000009 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1008) [PubMed icon] 19372390
10 OB_000010 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1009) [PubMed icon] 19372390
11 OB_000011 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
fog-3 Caenorhabditis elegans 172863 non-null recessive - unknown unknown
The fog-3(q470) allele has no effect on life-span. Other phenotypes: In fog-3 mutant animals cells that would normally become sperm differentiate into oocytes [[PubMed icon] 7713418]. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 100) [PubMed icon] 11799246
12 OB_000012 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1010) [PubMed icon] 19372390
13 OB_000013 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1011) [PubMed icon] 19372390
14 OB_000014 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1012) [PubMed icon] 19372390
15 OB_000015 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction Bacterial deprivation
Deletion of vhl-1 increased life span additively with dietary restriction by bacterial deprivation. These data support the model that VHL-1 and dietary restriction act in parallel pathways to promote longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1013) [PubMed icon] 19372390
16 OB_000016 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction Bacterial deprivation
Deletion of vhl-1 increased life span additively with dietary restriction by bacterial deprivation. These data support the model that VHL-1 and dietary restriction act in parallel pathways to promote longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1014) [PubMed icon] 19372390
17 OB_000017 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-16 Caenorhabditis elegans 172981 RNAi knockdown - unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1015) [PubMed icon] 19372390
18 OB_000018 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-16 Caenorhabditis elegans 172981 RNAi knockdown - unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1016) [PubMed icon] 19372390
19 OB_000019 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-2 Caenorhabditis elegans 175410 RNAi knockdown - unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1017) [PubMed icon] 19372390
20 OB_000020 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-2 Caenorhabditis elegans 175410 RNAi knockdown - unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1018) [PubMed icon] 19372390
21 OB_000021 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-2 Caenorhabditis elegans 175410 RNAi knockdown - unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1019) [PubMed icon] 19372390
22 OB_000022 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
che-3 Caenorhabditis elegans 172593 unknown e1124 unknown unknown
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 101) [PubMed icon] 10617200
23 OB_000023 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1020) [PubMed icon] 19372390
24 OB_000024 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1021) [PubMed icon] 19372390
25 OB_000025 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1022) [PubMed icon] 19372390
26 OB_000026 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1023) [PubMed icon] 19372390
27 OB_000027 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction Bacterial deprivation
Dietary restriction by bacterial deprivation significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that dietary restriction acts in a longevity pathway parallel to VHL-1/HIF-1. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1024) [PubMed icon] 19372390
28 OB_000028 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction Bacterial deprivation
Dietary restriction by bacterial deprivation significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that dietary restriction acts in a longevity pathway parallel to VHL-1/HIF-1. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1025) [PubMed icon] 19372390
29 OB_000029 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction Bacterial deprivation
RNAi knock-down of daf-2 significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that insulin-like signaling acts in a longevity pathway parallel to VHL-1/HIF-1. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1026) [PubMed icon] 19372390
30 OB_000030 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of vhl-1 significantly increased life span. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1027) [PubMed icon] 19372390
31 OB_000031 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1028) [PubMed icon] 19372390
32 OB_000032 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1029) [PubMed icon] 19372390
33 OB_000033 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daz-1 Caenorhabditis elegans 173931 non-null recessive - unknown unknown
Mutation of daz-1 has no effect on life span. Other phenotypes: daz-1 mutants are sterile and have a gonad that contains small nuclei and no oocytes [[PubMed icon] 10662646]. Sperm production is normal. Oocyte precursors arrest at meiotic prophase and undergo apoptosis. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 102) [PubMed icon] 11799246
34 OB_000034 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1030) [PubMed icon] 19372390
35 OB_000035 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1031) [PubMed icon] 19372390
36 OB_000036 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1032) [PubMed icon] 19372390
37 OB_000037 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1033) [PubMed icon] 19372390
38 OB_000038 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1034) [PubMed icon] 19372390
39 OB_000039 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1035) [PubMed icon] 19372390
40 OB_000040 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1036) [PubMed icon] 19372390
41 OB_000041 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1037) [PubMed icon] 19372390
42 OB_000042 ageing phenotype observation—data type 2 Mus musculus
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
Ins2 Mus musculus 16334 unknown Akita unknown unknown
Pparg Mus musculus 19016 non-null dominant P465L unknown unknown
Unlike Ins2(Akita/+) littermates, male Pparg(P465L/+)Ins2(Akita/+)mice have drastically reduced life-span with enhanced Type I diabetes. The Ins2-Akita mutation causes improper protein folding and islet apoptosis to lower plasma insulin. The Pparg(P465L) mutation is dominant negative. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1038) [PubMed icon] 20724579
43 OB_000043 ageing phenotype observation—data type 2 Homo sapiens
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CBX7 Homo sapiens 23492 RNAi knockdown - unknown unknown
Knockdown of CBX7 expression in gastric cancer cells led to increased cellular senescence, decreased cellular proliferation and migration ability, accompanied by upregulation of p16(INK4a). CBX7 may act as an oncogene in gastric cancer, and regulate tumorigenesis, cell migration and cancer metastasis partially via p16(INK4a) regulatory pathway. Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating expression of the INK4a/ARF tumor suppressor locus. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1039) [PubMed icon] 20723236
44 OB_000044 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SWI4 Saccharomyces cerevisiae 856847 deletion / null - unknown unknown
Deletion of SWI4 shortens life-span by approximately 90%. Other phenotypes: SSD1-V partially suppresses the short life-span of a swi4 mutant. Mutation of swi4 results in slow growth and temperature sensitivity, both of which are suppressed by SSD1-V. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 103) [PubMed icon] 11805047
45 OB_000045 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SIR2 Saccharomyces cerevisiae 851520 over-expression - unknown unknown
Integration of a second copy of SIR2 failed to significantly alter life span in the PSY316 strain background. This differs from the increased life span observed for SIR2-overexpression in wth W303 and BY4742 strain backgrounds. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1040) [PubMed icon] 15684413
46 OB_000046 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
BRE5 Saccharomyces cerevisiae 855787 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1048) [PubMed icon] 16293764
47 OB_000047 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
BRE5 Saccharomyces cerevisiae 855787 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1049) [PubMed icon] 16293764
48 OB_000048 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CCR4 Saccharomyces cerevisiae 851212 deletion / null - unknown unknown
Deletion of CCR4 shortens life-span by approximately 80%. Other phenotypes: SSD1-V partially suppresses the short life-span of a ccr4 mutant. Mutation of ccr4 results in temperature sensitivity that is suppressed by SSD1-V. Mutation of ccr4 is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 104) [PubMed icon] 11805047
49 OB_000049 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1050) [PubMed icon] 16293764
50 OB_000050 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1051) [PubMed icon] 16293764
51 OB_000051 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
IDH2 Saccharomyces cerevisiae 854303 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1052) [PubMed icon] 16293764
52 OB_000052 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
IDH2 Saccharomyces cerevisiae 854303 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1053) [PubMed icon] 16293764
53 OB_000053 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
REI1 Saccharomyces cerevisiae 852569 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1054) [PubMed icon] 16293764
54 OB_000054 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
REI1 Saccharomyces cerevisiae 852569 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1055) [PubMed icon] 16293764
55 OB_000055 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
REI1 Saccharomyces cerevisiae 852569 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1056) [PubMed icon] 16293764
56 OB_000056 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
ROM2 Saccharomyces cerevisiae 851086 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1057) [PubMed icon] 16293764
57 OB_000057 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
ROM2 Saccharomyces cerevisiae 851086 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1058) [PubMed icon] 16293764
58 OB_000058 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL31A Saccharomyces cerevisiae 851484 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1059) [PubMed icon] 16293764
59 OB_000059 ageing phenotype observation—data type 2 Caenorhabditis elegans
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
pgl-1 Caenorhabditis elegans 177461 non-null recessive - unknown unknown
pgl-1(bn101) animals that are sterile have a life-span that is approximately 35% longer than wild type animals. Other phenotypes: Fertile pgl-1(bn101) animals have a wild type life-span [[PubMed icon] 11799246]. PGL-1 is required for fertility and proliferation of germ line cells [[PubMed icon] 9741628]. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 105) [PubMed icon] 11799246
60 OB_000060 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL31A Saccharomyces cerevisiae 851484 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1060) [PubMed icon] 16293764
61 OB_000061 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL6B Saccharomyces cerevisiae 851169 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1061) [PubMed icon] 16293764
62 OB_000062 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL6B Saccharomyces cerevisiae 851169 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1062) [PubMed icon] 16293764
63 OB_000063 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL6B Saccharomyces cerevisiae 851169 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1063) [PubMed icon] 16293764
64 OB_000064 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1064) [PubMed icon] 16293764
65 OB_000065 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1065) [PubMed icon] 16293764
66 OB_000066 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1066) [PubMed icon] 16293764
67 OB_000067 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
URE2 Saccharomyces cerevisiae 855492 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1067) [PubMed icon] 16293764
68 OB_000068 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
URE2 Saccharomyces cerevisiae 855492 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1068) [PubMed icon] 16293764
69 OB_000069 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR238C Saccharomyces cerevisiae 852540 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1069) [PubMed icon] 16293764
70 OB_000070 ageing phenotype observation—data type 2 Drosophila melanogaster
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
chico Drosophila melanogaster 64880 non-null recessive - unknown unknown
Mutation of chico results in life-span extension of up to 48% in homozygous recessive female animals. Other phenotypes: Mutation of chico results in life-span extension of up to 36% in heterozygous females. Male heterozygotes live 13% longer than wild type, but male homozygous recessive animals have a shortened life-span [[PubMed icon] 11292874] Chico heterozygous females have reduced fecundity and homozygous recessive animals are sterile. Chico heterozygotes are resistant to starvation but not oxidative or temperature stress [[PubMed icon] 11292874]. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 106) [PubMed icon] 11292874
71 OB_000071 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR238C Saccharomyces cerevisiae 852540 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1070) [PubMed icon] 16293764
72 OB_000072 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR238C Saccharomyces cerevisiae 852540 deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1071) [PubMed icon] 16293764
73 OB_000073 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR255W Saccharomyces cerevisiae deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1072) [PubMed icon] 16293764
74 OB_000074 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR255W Saccharomyces cerevisiae deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1073) [PubMed icon] 16293764
75 OB_000075 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR255W Saccharomyces cerevisiae deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1074) [PubMed icon] 16293764
76 OB_000076 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR266C Saccharomyces cerevisiae deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YBR266C encodes a dubious ORF that overlaps REI1 and likely extends replicative life span due to loss of function of REI1. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1075) [PubMed icon] 16293764
77 OB_000077 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR266C Saccharomyces cerevisiae deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YBR266C encodes a dubious ORF that overlaps REI1 and likely extends replicative life span due to loss of function of REI1. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1076) [PubMed icon] 16293764
78 OB_000078 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YOR135W Saccharomyces cerevisiae deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YOR135W encodes a dubious ORF that overlaps IDH2 and likely extends replicative life span due to loss of function of IDH2. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1077) [PubMed icon] 16293764
79 OB_000079 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YOR135W Saccharomyces cerevisiae deletion / null - unknown unknown
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YOR135W encodes a dubious ORF that overlaps IDH2 and likely extends replicative life span due to loss of function of IDH2. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1078) [PubMed icon] 16293764
80 OB_000080 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
Deletion of TOR1 significantly increased replicative life span of BY4741 cells. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1079) [PubMed icon] 16293764
81 OB_000081 ageing phenotype observation—data type 2 Drosophila melanogaster
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
chico Drosophila melanogaster 64880 non-null recessive - unknown unknown
Mutation of chico results in life-span extension of up to 36% in heterozygous females. Other phenotypes: Mutation of chico results in life-span extension of up to 48% in homozygous recessive female animals. Male heterozygotes live 13% longer than wild type, but male homozygous recessive animals have a shortened life-span [[PubMed icon] 11292874] Chico heterozygous females have reduced fecundity and homozygous recessive animals are sterile. Chico heterozygotes are resistant to starvation but not oxidative or temperature stress [[PubMed icon] 11292874]. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 107) [PubMed icon] 11292874
82 OB_000082 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL31A Saccharomyces cerevisiae 851484 deletion / null - unknown unknown
Deletion of RPL31A significantly increased replicative life span of BY4741 cells. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1080) [PubMed icon] 16293764
83 OB_000083 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL6B Saccharomyces cerevisiae 851169 deletion / null - unknown unknown
Deletion of RPL6B significantly increased replicative life span of BY4741 cells. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1081) [PubMed icon] 16293764
84 OB_000084 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
Deletion of TOR1 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that TOR1 and dietary restriction act in the same pathway to promote longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1082) [PubMed icon] 16293764
85 OB_000085 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
Deletion of TOR1 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that TOR1 and dietary restriction act in the same pathway to promote longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1083) [PubMed icon] 16293764
86 OB_000086 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SCH9 Saccharomyces cerevisiae 856612 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
Deletion of SCH9 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that SCH9 and dietary restriction act in the same pathway to promote longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1086) [PubMed icon] 16293764
87 OB_000087 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SCH9 Saccharomyces cerevisiae 856612 deletion / null - unknown unknown
Deletion of SCH9 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that SCH9 and dietary restriction act in the same pathway to promote longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1087) [PubMed icon] 16293764
88 OB_000088 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1088) [PubMed icon] 16293764
89 OB_000089 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1089) [PubMed icon] 16293764
90 OB_000090 ageing phenotype observation—data type 2 Drosophila melanogaster
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
MSRA Drosophila melanogaster over-expression - unknown unknown
Flies engineered to overexpress methionine sulfoxide reductase A (MSRA) have a median lifespan up to 70% longer than parental controls that don''t overexpress the protein. Other phenotypes: Flies that overexpress MSRA retain reproductive capacity longer than parental controls that don''t overexpress the protein, and are more active, as measured by a climbing assay. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 108) [PubMed icon] 11867705
91 OB_000091 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1090) [PubMed icon] 16293764
92 OB_000092 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SCH9 Saccharomyces cerevisiae 856612 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
Deletion of TOR or SCH9 increase life span additively with deletion of FOB1 but not with dietary restriction. These data support the model that TOR, SCH9 and dietary restriction act in a single pathway that is distinct from the pathway that FOB1 acts in. Deletion of FOB1 is believed to increase replicative life span by reducing the accumulation of extrachromosomal rDNA circles (ERCs) in the mother cell [10207108]. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1091) [PubMed icon] 16293764
93 OB_000093 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [[PubMed icon] 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [[PubMed icon] 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1092) [PubMed icon] 16293764
94 OB_000094 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [[PubMed icon] 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [[PubMed icon] 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1093) [PubMed icon] 16293764
95 OB_000095 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SCH9 Saccharomyces cerevisiae 856612 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [[PubMed icon] 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [[PubMed icon] 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1094) [PubMed icon] 16293764
96 OB_000096 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
Deletion of TOR significantly increases the replicative life span of PSY316 mother cells. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1095) [PubMed icon] 16293764
97 OB_000097 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CIT2 Saccharomyces cerevisiae 850361 over-expression - unknown unknown
. Overexpression of CIT2 has no effect on life-span. Other phenotypes: Deletion of CIT2 has no effect on life-span [[PubMed icon] 10224252]. CIT2 is not required for the strain specific life-span extension in petite cells. Overexpression of CIT2 has no effect on life-span [[PubMed icon] 10224252]. CIT2 is transcribed up to 30-fold higher in petite cells relative to grande cells [[PubMed icon] 1986232]. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 109) [PubMed icon] 10224252
98 OB_000098 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
PHB1 Saccharomyces cerevisiae 853033 deletion / null - unknown unknown
Deletion of PHB1 results in approximately 20% shorter lifespan. Other phenotypes: Deletion of both PHB1 and PHB2 results in a life span that is approximately 40% shorter than wild type. Phenotypic changes characteristic of aging cells may suggest that PHB1/PHB2 mutants undergo premature aging, not simply reduction in viability. These changes include lengthening of cell cycle and characteristic morphological changes [[PubMed icon] 9259555]. No reduction in stress resistance or bulk growth rate. A strong defect in mitochondrial potential was detected in the phb1 phb2 double mutant, and a slight defect in the phb1 single mutant. Deletion of PHB1 is synthetically lethal [[PubMed icon] 9259555]. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 10) [PubMed icon] 9259555
99 OB_000099 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CYT1 Saccharomyces cerevisiae 854231 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
Deletion of CYT1 does not significantly influence replicative life span in the PSY316AUT strain background. Dietary restriction still increases the life span of CYT1 deletion mutants, demonstrating that mitochondrial respiration is not required for life span extension from dietary restriction in yeast. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1107) [PubMed icon] 16311627
100 OB_000100 ageing phenotype observation—data type 2 Saccharomyces cerevisiae
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CYT1 Saccharomyces cerevisiae 854231 deletion / null - unknown unknown
Deletion of CYT1 does not significantly influence replicative life span in the PSY316AUT strain background. Dietary restriction still increases the life span of CYT1 deletion mutants, demonstrating that mitochondrial respiration is not required for life span extension from dietary restriction in yeast. [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1109) [PubMed icon] 16311627