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Ageing Phenotype Observations List—Data Type 2

NOTE:

We distinguish between different types of ageing relevance evidence. Experimental studies on ageing factors result in observations with experimental ageing relevance evidence (1). According to our definition of ageing factors a comparison of two situations, with and without the action of the ageing factor, is required. Almost all data in AgeFactDB is of this type. There are however also a few lifespan data for populations or species included that are certainly relevant to ageing with a slightly different meaning of the term ageing relevance, however. But in this case there is no intervention study and therefore these data cannot be assigned to an ageing factor (2). Furthermore, there are experimental studies where no significant effect of an assumed ageing factor was found (3). And finally there are genes included that are homologous to known ageing-relevant genes for which there is no experimental evidence. They are considered as putative ageing-relevant genes with computational evidence (4).
Order of importance:

  1. yes (Experimental Analysis)
  2. yes, but no ageing factor assigned (Experimental Analysis)
  3. no (Experimental Analysis)
  4. putative (Computational Analysis)
The color indicating the ageing relevance type of an observation may differ from the corresponding color for the ageing factor related to this observation. The reason is that for ageing factors associated with more than one observation, the most important observation color is chosen as ageing factor color. This is always the color with the lowest number in the order given above.

Ageing phenotype observations are considered as experimental analysis. They confirm or reject the ageing relevance for particular ageing factor(s). For genes that are homologous to known ageing-relevant genes there is thus far no experimental evidence. They are considered as candidate genes.
Due to the different data structures of ageing phenotype observation data integrated from other databases we subdivide these observations into type 1 and 2. Observations of type 1 contain the phenotype data mostly unseparated within a single description. Observations of type 2 contain lifespan data in a more structured form (e.g.: separated into lifespan effect, lifespan change, lifespan value). Currently there might be an overlap between the observations of type 1 and 2 from the same source, namely GenAge. But we are working on a reduction of this overlap.

Ageing Relevance:
1 ... 100 [next icon]
Organism Ageing Factor Lifespan Observation Reference
# Observation Stable ID Species Strain Gene Compound Other Ageing Factor Significant Lifespan Effect Change Observed Lifespan Reference Lifespan Lifespan Unit Measure Temperature Temperature Unit Sex/Mating Type Description Author Year PubMed DOI Source
1 OB_000021 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-2 Caenorhabditis elegans 175410 RNAi knockdown - unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 165.82% 52.1 19.6 days mean 20 ℃ hermaphrodite RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1019)
2 OB_000020 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-2 Caenorhabditis elegans 175410 RNAi knockdown - unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 150.25% 49.3 19.7 days mean 20 ℃ hermaphrodite RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1018)
3 OB_000092 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SCH9 Saccharomyces cerevisiae 856612 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 116.18% 52.1 24.1 divisions mean 30 ℃ matalpha Deletion of TOR or SCH9 increase life span additively with deletion of FOB1 but not with dietary restriction. These data support the model that TOR, SCH9 and dietary restriction act in a single pathway that is distinct from the pathway that FOB1 acts in. Deletion of FOB1 is believed to increase replicative life span by reducing the accumulation of extrachromosomal rDNA circles (ERCs) in the mother cell [10207108]. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1091)
4 OB_000019 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-2 Caenorhabditis elegans 175410 RNAi knockdown - unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 76.50% 38.3 21.7 days mean 20 ℃ hermaphrodite RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1017)
5 OB_000015 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction Bacterial deprivation
increased 72.20% 41.5 24.1 days mean 20 ℃ hermaphrodite Deletion of vhl-1 increased life span additively with dietary restriction by bacterial deprivation. These data support the model that VHL-1 and dietary restriction act in parallel pathways to promote longevity. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1013)
6 OB_000016 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction Bacterial deprivation
increased 68.53% 39.1 23.2 days mean 20 ℃ hermaphrodite Deletion of vhl-1 increased life span additively with dietary restriction by bacterial deprivation. These data support the model that VHL-1 and dietary restriction act in parallel pathways to promote longevity. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1014)
7 OB_000089 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
increased 66.53% 40.3 24.2 divisions mean 30 ℃ matalpha Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1089)
8 OB_000012 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 61.73% 31.7 19.6 days mean 20 ℃ hermaphrodite Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1010)
9 OB_000082 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL31A Saccharomyces cerevisiae 851484 deletion / null - unknown unknown
increased 59.29% 40.3 25.3 divisions mean 30 ℃ mata Deletion of RPL31A significantly increased replicative life span of BY4741 cells. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1080)
10 OB_000060 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL31A Saccharomyces cerevisiae 851484 deletion / null - unknown unknown
increased 59.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1060)
11 OB_000037 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
increased 57.14% 29.7 18.9 days mean 20 ℃ hermaphrodite RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1033)
12 OB_000054 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
REI1 Saccharomyces cerevisiae 852569 deletion / null - unknown unknown
increased 52.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1055)
13 OB_000035 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
increased 51.85% 28.7 18.9 days mean 20 ℃ hermaphrodite RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1031)
14 OB_000009 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 51.61% 32.9 21.7 days mean 20 ℃ hermaphrodite Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1008)
15 OB_000027 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction Bacterial deprivation
increased 51.60% 33.2 21.9 days mean 20 ℃ hermaphrodite Dietary restriction by bacterial deprivation significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that dietary restriction acts in a longevity pathway parallel to VHL-1/HIF-1. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1024)
16 OB_000095 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SCH9 Saccharomyces cerevisiae 856612 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
increased 49.39% 36.6 24.5 divisions mean 30 ℃ matalpha Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [[PubMed icon] 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [[PubMed icon] 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1094)
17 OB_000028 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction Bacterial deprivation
increased 49.38% 36 24.1 days mean 20 ℃ hermaphrodite Dietary restriction by bacterial deprivation significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that dietary restriction acts in a longevity pathway parallel to VHL-1/HIF-1. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1025)
18 OB_000056 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
ROM2 Saccharomyces cerevisiae 851086 deletion / null - unknown unknown
increased 49.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1057)
19 OB_000055 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
REI1 Saccharomyces cerevisiae 852569 deletion / null - unknown unknown
increased 47.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1056)
20 OB_000077 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR266C Saccharomyces cerevisiae deletion / null - unknown unknown
increased 47.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YBR266C encodes a dubious ORF that overlaps REI1 and likely extends replicative life span due to loss of function of REI1. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1076)
21 OB_000010 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 46.19% 28.8 19.7 days mean 20 ℃ hermaphrodite Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1009)
22 OB_000006 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 42.92% 30.3 21.2 days mean 20 ℃ hermaphrodite Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1005)
23 OB_000050 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
increased 42.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1051)
24 OB_000087 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SCH9 Saccharomyces cerevisiae 856612 deletion / null - unknown unknown
increased 41.86% 36.6 25.8 divisions mean 30 ℃ matalpha Deletion of SCH9 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that SCH9 and dietary restriction act in the same pathway to promote longevity. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1087)
25 OB_000053 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
REI1 Saccharomyces cerevisiae 852569 deletion / null - unknown unknown
increased 38.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1054)
26 OB_000076 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR266C Saccharomyces cerevisiae deletion / null - unknown unknown
increased 37.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YBR266C encodes a dubious ORF that overlaps REI1 and likely extends replicative life span due to loss of function of REI1. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1075)
27 OB_000022 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
che-3 Caenorhabditis elegans 172593 unknown e1124 unknown unknown
increased 36.70% 25.7 18.8 days mean 20 ℃ hermaphrodite Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. Apfeld et al. 1999 10617200 [DOI icon]doi:10.1038/45544 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 101)
28 OB_000005 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 36.52% 31.4 23 days mean 20 ℃ hermaphrodite Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1004)
29 OB_000099 Saccharomyces cerevisiae PSY316AUT
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CYT1 Saccharomyces cerevisiae 854231 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 35.85% 28.8 21.2 divisions mean 30 ℃ matalpha Deletion of CYT1 does not significantly influence replicative life span in the PSY316AUT strain background. Dietary restriction still increases the life span of CYT1 deletion mutants, demonstrating that mitochondrial respiration is not required for life span extension from dietary restriction in yeast. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1107)
30 OB_000058 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL31A Saccharomyces cerevisiae 851484 deletion / null - unknown unknown
increased 35.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1059)
31 OB_000072 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR238C Saccharomyces cerevisiae 852540 deletion / null - unknown unknown
increased 34.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1071)
32 OB_000074 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR255W Saccharomyces cerevisiae deletion / null - unknown unknown
increased 34.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1073)
33 OB_000094 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
increased 33.47% 32.7 24.5 divisions mean 30 ℃ matalpha Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [[PubMed icon] 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [[PubMed icon] 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1093)
34 OB_000061 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL6B Saccharomyces cerevisiae 851169 deletion / null - unknown unknown
increased 33.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1061)
35 OB_000083 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL6B Saccharomyces cerevisiae 851169 deletion / null - unknown unknown
increased 32.41% 33.5 25.3 divisions mean 30 ℃ mata Deletion of RPL6B significantly increased replicative life span of BY4741 cells. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1081)
36 OB_000017 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-16 Caenorhabditis elegans 172981 RNAi knockdown - unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 31.12% 25.7 19.6 days mean 20 ℃ hermaphrodite RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1015)
37 OB_000051 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
IDH2 Saccharomyces cerevisiae 854303 deletion / null - unknown unknown
increased 31.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1052)
38 OB_000007 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 30.89% 32.2 24.6 days mean 20 ℃ hermaphrodite Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1006)
39 OB_000047 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
BRE5 Saccharomyces cerevisiae 855787 deletion / null - unknown unknown
increased 30.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1049)
40 OB_000029 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction Bacterial deprivation
increased 29.95% 28.2 21.7 days mean 20 ℃ hermaphrodite RNAi knock-down of daf-2 significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that insulin-like signaling acts in a longevity pathway parallel to VHL-1/HIF-1. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1026)
41 OB_000008 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 29.88% 31.3 24.1 days mean 20 ℃ hermaphrodite Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1007)
42 OB_000046 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
BRE5 Saccharomyces cerevisiae 855787 deletion / null - unknown unknown
increased 29.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1048)
43 OB_000014 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 28.45% 29.8 23.2 days mean 20 ℃ hermaphrodite Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1012)
44 OB_000031 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
increased 25.87% 25.3 20.1 days mean 20 ℃ hermaphrodite RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1028)
45 OB_000080 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
increased 25.30% 31.7 25.3 divisions mean 30 ℃ mata Deletion of TOR1 significantly increased replicative life span of BY4741 cells. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1079)
46 OB_000069 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR238C Saccharomyces cerevisiae 852540 deletion / null - unknown unknown
increased 25.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1069)
47 OB_000073 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR255W Saccharomyces cerevisiae deletion / null - unknown unknown
increased 25.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1072)
48 OB_000036 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
increased 24.06% 23.2 18.7 days mean 20 ℃ hermaphrodite RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1032)
49 OB_000062 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL6B Saccharomyces cerevisiae 851169 deletion / null - unknown unknown
increased 23.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1062)
50 OB_000063 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
RPL6B Saccharomyces cerevisiae 851169 deletion / null - unknown unknown
increased 23.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1063)
51 OB_000064 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
increased 23.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1064)
52 OB_000032 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
increased 22.64% 26 21.2 days mean 20 ℃ hermaphrodite RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1029)
53 OB_000088 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
increased 22.31% 29.6 24.2 divisions mean 30 ℃ matalpha Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1088)
54 OB_000091 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
increased 22.31% 29.6 24.2 divisions mean 30 ℃ matalpha Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1090)
55 OB_000066 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
increased 22.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1066)
56 OB_000079 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YOR135W Saccharomyces cerevisiae deletion / null - unknown unknown
increased 22.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YOR135W encodes a dubious ORF that overlaps IDH2 and likely extends replicative life span due to loss of function of IDH2. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1078)
57 OB_000084 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
increased 21.28% 28.5 23.5 divisions mean 30 ℃ matalpha Deletion of TOR1 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that TOR1 and dietary restriction act in the same pathway to promote longevity. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1082)
58 OB_000049 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
increased 21.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1050)
59 OB_000065 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
increased 21.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1065)
60 OB_000067 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
URE2 Saccharomyces cerevisiae 855492 deletion / null - unknown unknown
increased 21.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1067)
61 OB_000071 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR238C Saccharomyces cerevisiae 852540 deletion / null - unknown unknown
increased 21.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1070)
62 OB_000085 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 20.43% 28.3 23.5 divisions mean 30 ℃ matalpha Deletion of TOR1 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that TOR1 and dietary restriction act in the same pathway to promote longevity. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1083)
63 OB_000096 Saccharomyces cerevisiae PSY316
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
TOR1 Saccharomyces cerevisiae 853529 deletion / null - unknown unknown
increased 19.25% 25.4 21.3 divisions mean 30 ℃ matalpha Deletion of TOR significantly increases the replicative life span of PSY316 mother cells. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1095)
64 OB_000075 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YBR255W Saccharomyces cerevisiae deletion / null - unknown unknown
increased 19.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1074)
65 OB_000034 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
increased 18.44% 28.9 24.4 days mean 20 ℃ hermaphrodite RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1030)
66 OB_000052 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
IDH2 Saccharomyces cerevisiae 854303 deletion / null - unknown unknown
increased 18.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1053)
67 OB_000078 Saccharomyces cerevisiae BY4741
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
YOR135W Saccharomyces cerevisiae deletion / null - unknown unknown
increased 18.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YOR135W encodes a dubious ORF that overlaps IDH2 and likely extends replicative life span due to loss of function of IDH2. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1077)
68 OB_000057 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
ROM2 Saccharomyces cerevisiae 851086 deletion / null - unknown unknown
increased 16.00% divisions mean 30 ℃ mata 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1058)
69 OB_000086 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SCH9 Saccharomyces cerevisiae 856612 deletion / null - unknown unknown
Other Ageing Factor Name Additional Information
Dietary restriction 0.05% glucose
increased 15.50% 29.8 25.8 divisions mean 30 ℃ matalpha Deletion of SCH9 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that SCH9 and dietary restriction act in the same pathway to promote longevity. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1086)
70 OB_000068 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
URE2 Saccharomyces cerevisiae 855492 deletion / null - unknown unknown
increased 15.00% divisions mean 30 ℃ matalpha 13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1068)
71 OB_000013 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
increased 12.45% 28.9 25.7 days mean 20 ℃ hermaphrodite Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1011)
72 OB_000030 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
increased 11.92% 21.6 19.3 days mean 20 ℃ hermaphrodite RNAi knock-down of vhl-1 significantly increased life span. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1027)
73 OB_000038 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
increased 11.63% 24 21.5 days mean 20 ℃ hermaphrodite RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1034)
74 OB_000033 Caenorhabditis elegans Bristol N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daz-1 Caenorhabditis elegans 173931 non-null recessive - unknown unknown
increased 8.81% 21 19.3 days mean 20 ℃ hermaphrodite Mutation of daz-1 has no effect on life span. Other phenotypes: daz-1 mutants are sterile and have a gonad that contains small nuclei and no oocytes [[PubMed icon] 10662646]. Sperm production is normal. Oocyte precursors arrest at meiotic prophase and undergo apoptosis. Arantes-Oliveira et al. 2002 11799246 [DOI icon]doi:10.1126/science.1065768 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 102)
75 OB_000041 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
increased 7.11% 22.6 21.1 days mean 20 ℃ hermaphrodite RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1037)
76 OB_000040 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
none 3.69% 25.3 24.4 days mean 20 ℃ hermaphrodite RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1036)
77 OB_000100 Saccharomyces cerevisiae PSY316AUT
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CYT1 Saccharomyces cerevisiae 854231 deletion / null - unknown unknown
none 2.83% 21.8 21.2 divisions mean 30 ℃ matalpha Deletion of CYT1 does not significantly influence replicative life span in the PSY316AUT strain background. Dietary restriction still increases the life span of CYT1 deletion mutants, demonstrating that mitochondrial respiration is not required for life span extension from dietary restriction in yeast. Kaeberlein et al. 2005 16311627 [DOI icon]doi:10.1371/journal.pgen.0010069 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1109)
78 OB_000093 Saccharomyces cerevisiae BY4742
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
FOB1 Saccharomyces cerevisiae 851688 deletion / null - unknown unknown
SIR2 Saccharomyces cerevisiae 851520 deletion / null - unknown unknown
none 2.45% 25.1 24.5 divisions mean 30 ℃ matalpha Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [[PubMed icon] 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [[PubMed icon] 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. Kaeberlein et al. 2005 16293764 [DOI icon]doi:10.1126/science.1115535 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1092)
79 OB_000025 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
none 1.22% 24.8 24.5 days mean 20 ℃ hermaphrodite Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1022)
80 OB_000001 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
none 0.00% 24.4 24.4 days mean 20 ℃ hermaphrodite RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1000)
81 OB_000039 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
vhl-1 Caenorhabditis elegans 181321 RNAi knockdown - unknown unknown
none -0.93% 21.4 21.6 days mean 20 ℃ hermaphrodite RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1035)
82 OB_000026 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
none -1.66% 23.7 24.1 days mean 20 ℃ hermaphrodite Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1023)
83 OB_000045 Saccharomyces cerevisiae PSY316AT
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SIR2 Saccharomyces cerevisiae 851520 over-expression - unknown unknown
none -2.58% 22.7 23.3 divisions mean 30 ℃ matalpha Integration of a second copy of SIR2 failed to significantly alter life span in the PSY316 strain background. This differs from the increased life span observed for SIR2-overexpression in wth W303 and BY4742 strain backgrounds. Kaeberlein et al. 2005 15684413 [DOI icon]doi:10.1074/jbc.M500655200 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1040)
84 OB_000024 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
none -2.76% 21.1 21.7 days mean 20 ℃ hermaphrodite Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1021)
85 OB_000002 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
none -4.23% 18.1 18.9 days mean 20 ℃ hermaphrodite RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1001)
86 OB_000004 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
none -4.25% 20.3 21.2 days mean 20 ℃ hermaphrodite RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1003)
87 OB_000003 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans RNAi knockdown - unknown unknown
rrf-3 Caenorhabditis elegans 174315 loss of function pk1426 unknown unknown
decreased -8.37% 19.7 21.5 days mean 20 ℃ hermaphrodite RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1002)
88 OB_000018 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
daf-16 Caenorhabditis elegans 172981 RNAi knockdown - unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
decreased -8.95% 23.4 25.7 days mean 20 ℃ hermaphrodite RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1016)
89 OB_000023 Caenorhabditis elegans N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
hif-1 Caenorhabditis elegans deletion / null ia04 unknown unknown
vhl-1 Caenorhabditis elegans 181321 deletion / null ok161 unknown unknown
decreased -10.05% 19.7 21.9 days mean 20 ℃ hermaphrodite Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. Mehta et al. 2009 19372390 [DOI icon]doi:10.1126/science.1173507 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1020)
90 OB_000011 Caenorhabditis elegans Bristol N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
fog-3 Caenorhabditis elegans 172863 non-null recessive - unknown unknown
none The fog-3(q470) allele has no effect on life-span. Other phenotypes: In fog-3 mutant animals cells that would normally become sperm differentiate into oocytes [[PubMed icon] 7713418]. Arantes-Oliveira et al. 2002 11799246 [DOI icon]doi:10.1126/science.1065768 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 100)
91 OB_000042 Mus musculus
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
Ins2 Mus musculus 16334 unknown Akita unknown unknown
Pparg Mus musculus 19016 non-null dominant P465L unknown unknown
decreased days median female Unlike Ins2(Akita/+) littermates, male Pparg(P465L/+)Ins2(Akita/+)mice have drastically reduced life-span with enhanced Type I diabetes. The Ins2-Akita mutation causes improper protein folding and islet apoptosis to lower plasma insulin. The Pparg(P465L) mutation is dominant negative. Pendse et al. 2010 20724579 [DOI icon]doi:10.2337/db10-0673 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1038)
92 OB_000043 Homo sapiens SGC-7901
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CBX7 Homo sapiens 23492 RNAi knockdown - unknown unknown
decreased divisions median diploid Knockdown of CBX7 expression in gastric cancer cells led to increased cellular senescence, decreased cellular proliferation and migration ability, accompanied by upregulation of p16(INK4a). CBX7 may act as an oncogene in gastric cancer, and regulate tumorigenesis, cell migration and cancer metastasis partially via p16(INK4a) regulatory pathway. Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating expression of the INK4a/ARF tumor suppressor locus. Zhang et al. 2010 20723236 [DOI icon]doi:10.1186/1756-9966-29-114 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 1039)
93 OB_000044 Saccharomyces cerevisiae W303R
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
SWI4 Saccharomyces cerevisiae 856847 deletion / null - unknown unknown
decreased Deletion of SWI4 shortens life-span by approximately 90%. Other phenotypes: SSD1-V partially suppresses the short life-span of a swi4 mutant. Mutation of swi4 results in slow growth and temperature sensitivity, both of which are suppressed by SSD1-V. Kaeberlein et al. 2002 11805047 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 103)
94 OB_000048 Saccharomyces cerevisiae W303R
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CCR4 Saccharomyces cerevisiae 851212 deletion / null - unknown unknown
decreased Deletion of CCR4 shortens life-span by approximately 80%. Other phenotypes: SSD1-V partially suppresses the short life-span of a ccr4 mutant. Mutation of ccr4 results in temperature sensitivity that is suppressed by SSD1-V. Mutation of ccr4 is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V. Kaeberlein et al. 2002 11805047 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 104)
95 OB_000059 Caenorhabditis elegans Bristol N2
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
pgl-1 Caenorhabditis elegans 177461 non-null recessive - unknown unknown
increased pgl-1(bn101) animals that are sterile have a life-span that is approximately 35% longer than wild type animals. Other phenotypes: Fertile pgl-1(bn101) animals have a wild type life-span [[PubMed icon] 11799246]. PGL-1 is required for fertility and proliferation of germ line cells [[PubMed icon] 9741628]. Arantes-Oliveira et al. 2002 11799246 [DOI icon]doi:10.1126/science.1065768 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 105)
96 OB_000070 Drosophila melanogaster
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
chico Drosophila melanogaster 64880 non-null recessive - unknown unknown
increased Mutation of chico results in life-span extension of up to 48% in homozygous recessive female animals. Other phenotypes: Mutation of chico results in life-span extension of up to 36% in heterozygous females. Male heterozygotes live 13% longer than wild type, but male homozygous recessive animals have a shortened life-span [[PubMed icon] 11292874] Chico heterozygous females have reduced fecundity and homozygous recessive animals are sterile. Chico heterozygotes are resistant to starvation but not oxidative or temperature stress [[PubMed icon] 11292874]. Clancy et al. 2001 11292874 [DOI icon]doi:10.1126/science.1057991 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 106)
97 OB_000081 Drosophila melanogaster
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
chico Drosophila melanogaster 64880 non-null recessive - unknown unknown
increased Mutation of chico results in life-span extension of up to 36% in heterozygous females. Other phenotypes: Mutation of chico results in life-span extension of up to 48% in homozygous recessive female animals. Male heterozygotes live 13% longer than wild type, but male homozygous recessive animals have a shortened life-span [[PubMed icon] 11292874] Chico heterozygous females have reduced fecundity and homozygous recessive animals are sterile. Chico heterozygotes are resistant to starvation but not oxidative or temperature stress [[PubMed icon] 11292874]. Clancy et al. 2001 11292874 [DOI icon]doi:10.1126/science.1057991 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 107)
98 OB_000090 Drosophila melanogaster
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
MSRA Drosophila melanogaster over-expression - unknown unknown
increased Flies engineered to overexpress methionine sulfoxide reductase A (MSRA) have a median lifespan up to 70% longer than parental controls that don''t overexpress the protein. Other phenotypes: Flies that overexpress MSRA retain reproductive capacity longer than parental controls that don''t overexpress the protein, and are more active, as measured by a climbing assay. Ruan et al. 2002 11867705 [DOI icon]doi:10.1073/pnas.032671199 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 108)
99 OB_000097 Saccharomyces cerevisiae YPK9
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
CIT2 Saccharomyces cerevisiae 850361 over-expression - unknown unknown
none . Overexpression of CIT2 has no effect on life-span. Other phenotypes: Deletion of CIT2 has no effect on life-span [[PubMed icon] 10224252]. CIT2 is not required for the strain specific life-span extension in petite cells. Overexpression of CIT2 has no effect on life-span [[PubMed icon] 10224252]. CIT2 is transcribed up to 30-fold higher in petite cells relative to grande cells [[PubMed icon] 1986232]. Kirchman et al. 1999 10224252 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 109)
100 OB_000098 Saccharomyces cerevisiae S150-2B
Gene Symbol Species NCBI Gene ID Allele Type Allele Name Reference Allele Type Allele Change
PHB1 Saccharomyces cerevisiae 853033 deletion / null - unknown unknown
decreased Deletion of PHB1 results in approximately 20% shorter lifespan. Other phenotypes: Deletion of both PHB1 and PHB2 results in a life span that is approximately 40% shorter than wild type. Phenotypic changes characteristic of aging cells may suggest that PHB1/PHB2 mutants undergo premature aging, not simply reduction in viability. These changes include lengthening of cell cycle and characteristic morphological changes [[PubMed icon] 9259555]. No reduction in stress resistance or bulk growth rate. A strong defect in mitochondrial potential was detected in the phb1 phb2 double mutant, and a slight defect in the phb1 single mutant. Deletion of PHB1 is synthetically lethal [[PubMed icon] 9259555]. Coates et al. 1997 9259555 [Lifespan Observations Database icon]Lifespan Observations Database (ID: 10)