1 |
OB_000001 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1000) |
19372390 |
2 |
OB_000002 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1001) |
19372390 |
3 |
OB_000003 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1002) |
19372390 |
4 |
OB_000004 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
|
|
|
RNAi knock-down of hif-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1003) |
19372390 |
5 |
OB_000005 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Lifespan Observations Database (ID: 1004) |
19372390 |
6 |
OB_000006 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Lifespan Observations Database (ID: 1005) |
19372390 |
7 |
OB_000007 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Lifespan Observations Database (ID: 1006) |
19372390 |
8 |
OB_000008 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Lifespan Observations Database (ID: 1007) |
19372390 |
9 |
OB_000009 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Lifespan Observations Database (ID: 1008) |
19372390 |
10 |
OB_000010 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Lifespan Observations Database (ID: 1009) |
19372390 |
11 |
OB_000011 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
fog-3 |
Caenorhabditis elegans |
172863 |
non-null recessive |
- |
unknown |
unknown |
|
|
|
The fog-3(q470) allele has no effect on life-span. Other phenotypes: In fog-3 mutant animals cells that would normally become sperm differentiate into oocytes [ 7713418]. |
Lifespan Observations Database (ID: 100) |
11799246 |
12 |
OB_000012 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Lifespan Observations Database (ID: 1010) |
19372390 |
13 |
OB_000013 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Lifespan Observations Database (ID: 1011) |
19372390 |
14 |
OB_000014 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of vhl-1 significantly increased life span. VHL-1 is a negative regulator of HIF-1 and vhl-1(ok161) animals have increased levels of HIF-1 protein and show constitutive activation of HIF-1 target genes under normoxic conditions. |
Lifespan Observations Database (ID: 1012) |
19372390 |
15 |
OB_000015 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
Deletion of vhl-1 increased life span additively with dietary restriction by bacterial deprivation. These data support the model that VHL-1 and dietary restriction act in parallel pathways to promote longevity. |
Lifespan Observations Database (ID: 1013) |
19372390 |
16 |
OB_000016 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
Deletion of vhl-1 increased life span additively with dietary restriction by bacterial deprivation. These data support the model that VHL-1 and dietary restriction act in parallel pathways to promote longevity. |
Lifespan Observations Database (ID: 1014) |
19372390 |
17 |
OB_000017 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Lifespan Observations Database (ID: 1015) |
19372390 |
18 |
OB_000018 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-16 |
Caenorhabditis elegans |
172981 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
RNAi knock-down of daf-16 failed to prevent life span extension from deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Lifespan Observations Database (ID: 1016) |
19372390 |
19 |
OB_000019 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Lifespan Observations Database (ID: 1017) |
19372390 |
20 |
OB_000020 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Lifespan Observations Database (ID: 1018) |
19372390 |
21 |
OB_000021 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daf-2 |
Caenorhabditis elegans |
175410 |
RNAi knockdown |
- |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
RNAi knock-down of daf-2 increased life span additively with deletion of vhl-1. These data support the model that VHL-1 and insulin-like signaling act in parallel pathways to modulate longevity. |
Lifespan Observations Database (ID: 1019) |
19372390 |
22 |
OB_000022 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
che-3 |
Caenorhabditis elegans |
172593 |
unknown |
e1124 |
unknown |
unknown |
|
|
|
Several (but not all) mutations that cause defects in sensory cilia or their support cells, or in sensory signal transduction, extend lifespan. |
Lifespan Observations Database (ID: 101) |
10617200 |
23 |
OB_000023 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Lifespan Observations Database (ID: 1020) |
19372390 |
24 |
OB_000024 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Lifespan Observations Database (ID: 1021) |
19372390 |
25 |
OB_000025 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Lifespan Observations Database (ID: 1022) |
19372390 |
26 |
OB_000026 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
|
Deletion of hif-1 suppressed the life span extension of vhl-1(ok161) mutants. These data support the model that deletion of VHL-1 promotes longevity by activating HIF-1. |
Lifespan Observations Database (ID: 1023) |
19372390 |
27 |
OB_000027 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
Dietary restriction by bacterial deprivation significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that dietary restriction acts in a longevity pathway parallel to VHL-1/HIF-1. |
Lifespan Observations Database (ID: 1024) |
19372390 |
28 |
OB_000028 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
Dietary restriction by bacterial deprivation significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that dietary restriction acts in a longevity pathway parallel to VHL-1/HIF-1. |
Lifespan Observations Database (ID: 1025) |
19372390 |
29 |
OB_000029 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
deletion / null |
ia04 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
deletion / null |
ok161 |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
Bacterial deprivation |
|
RNAi knock-down of daf-2 significantly increased the life span of vhl-1(ok161); hif-1(ia04) double mutant animals. These data support the model that insulin-like signaling acts in a longevity pathway parallel to VHL-1/HIF-1. |
Lifespan Observations Database (ID: 1026) |
19372390 |
30 |
OB_000030 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of vhl-1 significantly increased life span. |
Lifespan Observations Database (ID: 1027) |
19372390 |
31 |
OB_000031 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1028) |
19372390 |
32 |
OB_000032 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1029) |
19372390 |
33 |
OB_000033 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
daz-1 |
Caenorhabditis elegans |
173931 |
non-null recessive |
- |
unknown |
unknown |
|
|
|
Mutation of daz-1 has no effect on life span. Other phenotypes: daz-1 mutants are sterile and have a gonad that contains small nuclei and no oocytes [ 10662646]. Sperm production is normal. Oocyte precursors arrest at meiotic prophase and undergo apoptosis. |
Lifespan Observations Database (ID: 102) |
11799246 |
34 |
OB_000034 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1030) |
19372390 |
35 |
OB_000035 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1031) |
19372390 |
36 |
OB_000036 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1032) |
19372390 |
37 |
OB_000037 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1033) |
19372390 |
38 |
OB_000038 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of vhl-1 significantly increased life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1034) |
19372390 |
39 |
OB_000039 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1035) |
19372390 |
40 |
OB_000040 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1036) |
19372390 |
41 |
OB_000041 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
hif-1 |
Caenorhabditis elegans |
|
RNAi knockdown |
- |
unknown |
unknown |
rrf-3 |
Caenorhabditis elegans |
174315 |
loss of function |
pk1426 |
unknown |
unknown |
vhl-1 |
Caenorhabditis elegans |
181321 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
RNAi knock-down of both hif-1 and vhl-1 had no significant effect on life span in the RNAi sensitive rrf-3(pk1426) background. |
Lifespan Observations Database (ID: 1037) |
19372390 |
42 |
OB_000042 |
2 |
Mus musculus |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
Ins2 |
Mus musculus |
16334 |
unknown |
Akita |
unknown |
unknown |
Pparg |
Mus musculus |
19016 |
non-null dominant |
P465L |
unknown |
unknown |
|
|
|
Unlike Ins2(Akita/+) littermates, male Pparg(P465L/+)Ins2(Akita/+)mice have drastically reduced life-span with enhanced Type I diabetes. The Ins2-Akita mutation causes improper protein folding and islet apoptosis to lower plasma insulin. The Pparg(P465L) mutation is dominant negative. |
Lifespan Observations Database (ID: 1038) |
20724579 |
43 |
OB_000043 |
2 |
Homo sapiens |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CBX7 |
Homo sapiens |
23492 |
RNAi knockdown |
- |
unknown |
unknown |
|
|
|
Knockdown of CBX7 expression in gastric cancer cells led to increased cellular senescence, decreased cellular proliferation and migration ability, accompanied by upregulation of p16(INK4a). CBX7 may act as an oncogene in gastric cancer, and regulate tumorigenesis, cell migration and cancer metastasis partially via p16(INK4a) regulatory pathway. Chromobox 7 (CBX7) is a Polycomb family protein that extends the lifespan of normal human cells via downregulating expression of the INK4a/ARF tumor suppressor locus. |
Lifespan Observations Database (ID: 1039) |
20723236 |
44 |
OB_000044 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SWI4 |
Saccharomyces cerevisiae |
856847 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of SWI4 shortens life-span by approximately 90%. Other phenotypes: SSD1-V partially suppresses the short life-span of a swi4 mutant. Mutation of swi4 results in slow growth and temperature sensitivity, both of which are suppressed by SSD1-V. |
Lifespan Observations Database (ID: 103) |
11805047 |
45 |
OB_000045 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SIR2 |
Saccharomyces cerevisiae |
851520 |
over-expression |
- |
unknown |
unknown |
|
|
|
Integration of a second copy of SIR2 failed to significantly alter life span in the PSY316 strain background. This differs from the increased life span observed for SIR2-overexpression in wth W303 and BY4742 strain backgrounds. |
Lifespan Observations Database (ID: 1040) |
15684413 |
46 |
OB_000046 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
BRE5 |
Saccharomyces cerevisiae |
855787 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1048) |
16293764 |
47 |
OB_000047 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
BRE5 |
Saccharomyces cerevisiae |
855787 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1049) |
16293764 |
48 |
OB_000048 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CCR4 |
Saccharomyces cerevisiae |
851212 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of CCR4 shortens life-span by approximately 80%. Other phenotypes: SSD1-V partially suppresses the short life-span of a ccr4 mutant. Mutation of ccr4 results in temperature sensitivity that is suppressed by SSD1-V. Mutation of ccr4 is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V. |
Lifespan Observations Database (ID: 104) |
11805047 |
49 |
OB_000049 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1050) |
16293764 |
50 |
OB_000050 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1051) |
16293764 |
51 |
OB_000051 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
IDH2 |
Saccharomyces cerevisiae |
854303 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1052) |
16293764 |
52 |
OB_000052 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
IDH2 |
Saccharomyces cerevisiae |
854303 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1053) |
16293764 |
53 |
OB_000053 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
REI1 |
Saccharomyces cerevisiae |
852569 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1054) |
16293764 |
54 |
OB_000054 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
REI1 |
Saccharomyces cerevisiae |
852569 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1055) |
16293764 |
55 |
OB_000055 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
REI1 |
Saccharomyces cerevisiae |
852569 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1056) |
16293764 |
56 |
OB_000056 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ROM2 |
Saccharomyces cerevisiae |
851086 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1057) |
16293764 |
57 |
OB_000057 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
ROM2 |
Saccharomyces cerevisiae |
851086 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1058) |
16293764 |
58 |
OB_000058 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPL31A |
Saccharomyces cerevisiae |
851484 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1059) |
16293764 |
59 |
OB_000059 |
2 |
Caenorhabditis elegans |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
pgl-1 |
Caenorhabditis elegans |
177461 |
non-null recessive |
- |
unknown |
unknown |
|
|
|
pgl-1(bn101) animals that are sterile have a life-span that is approximately 35% longer than wild type animals. Other phenotypes: Fertile pgl-1(bn101) animals have a wild type life-span [ 11799246]. PGL-1 is required for fertility and proliferation of germ line cells [ 9741628]. |
Lifespan Observations Database (ID: 105) |
11799246 |
60 |
OB_000060 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPL31A |
Saccharomyces cerevisiae |
851484 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1060) |
16293764 |
61 |
OB_000061 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPL6B |
Saccharomyces cerevisiae |
851169 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1061) |
16293764 |
62 |
OB_000062 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPL6B |
Saccharomyces cerevisiae |
851169 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1062) |
16293764 |
63 |
OB_000063 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPL6B |
Saccharomyces cerevisiae |
851169 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1063) |
16293764 |
64 |
OB_000064 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1064) |
16293764 |
65 |
OB_000065 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1065) |
16293764 |
66 |
OB_000066 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1066) |
16293764 |
67 |
OB_000067 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
URE2 |
Saccharomyces cerevisiae |
855492 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1067) |
16293764 |
68 |
OB_000068 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
URE2 |
Saccharomyces cerevisiae |
855492 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1068) |
16293764 |
69 |
OB_000069 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YBR238C |
Saccharomyces cerevisiae |
852540 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1069) |
16293764 |
70 |
OB_000070 |
2 |
Drosophila melanogaster |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
chico |
Drosophila melanogaster |
64880 |
non-null recessive |
- |
unknown |
unknown |
|
|
|
Mutation of chico results in life-span extension of up to 48% in homozygous recessive female animals. Other phenotypes: Mutation of chico results in life-span extension of up to 36% in heterozygous females. Male heterozygotes live 13% longer than wild type, but male homozygous recessive animals have a shortened life-span [ 11292874] Chico heterozygous females have reduced fecundity and homozygous recessive animals are sterile. Chico heterozygotes are resistant to starvation but not oxidative or temperature stress [ 11292874]. |
Lifespan Observations Database (ID: 106) |
11292874 |
71 |
OB_000071 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YBR238C |
Saccharomyces cerevisiae |
852540 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1070) |
16293764 |
72 |
OB_000072 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YBR238C |
Saccharomyces cerevisiae |
852540 |
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1071) |
16293764 |
73 |
OB_000073 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YBR255W |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1072) |
16293764 |
74 |
OB_000074 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YBR255W |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1073) |
16293764 |
75 |
OB_000075 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YBR255W |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. |
Lifespan Observations Database (ID: 1074) |
16293764 |
76 |
OB_000076 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YBR266C |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YBR266C encodes a dubious ORF that overlaps REI1 and likely extends replicative life span due to loss of function of REI1. |
Lifespan Observations Database (ID: 1075) |
16293764 |
77 |
OB_000077 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YBR266C |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YBR266C encodes a dubious ORF that overlaps REI1 and likely extends replicative life span due to loss of function of REI1. |
Lifespan Observations Database (ID: 1076) |
16293764 |
78 |
OB_000078 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YOR135W |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YOR135W encodes a dubious ORF that overlaps IDH2 and likely extends replicative life span due to loss of function of IDH2. |
Lifespan Observations Database (ID: 1077) |
16293764 |
79 |
OB_000079 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
YOR135W |
Saccharomyces cerevisiae |
|
deletion / null |
- |
unknown |
unknown |
|
|
|
13 genes were identified as long-lived in both haploid mating types from a screen of 564 single-gene deletion strains from the yeast ORF deletion collection. YOR135W encodes a dubious ORF that overlaps IDH2 and likely extends replicative life span due to loss of function of IDH2. |
Lifespan Observations Database (ID: 1078) |
16293764 |
80 |
OB_000080 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of TOR1 significantly increased replicative life span of BY4741 cells. |
Lifespan Observations Database (ID: 1079) |
16293764 |
81 |
OB_000081 |
2 |
Drosophila melanogaster |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
chico |
Drosophila melanogaster |
64880 |
non-null recessive |
- |
unknown |
unknown |
|
|
|
Mutation of chico results in life-span extension of up to 36% in heterozygous females. Other phenotypes: Mutation of chico results in life-span extension of up to 48% in homozygous recessive female animals. Male heterozygotes live 13% longer than wild type, but male homozygous recessive animals have a shortened life-span [ 11292874] Chico heterozygous females have reduced fecundity and homozygous recessive animals are sterile. Chico heterozygotes are resistant to starvation but not oxidative or temperature stress [ 11292874]. |
Lifespan Observations Database (ID: 107) |
11292874 |
82 |
OB_000082 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPL31A |
Saccharomyces cerevisiae |
851484 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of RPL31A significantly increased replicative life span of BY4741 cells. |
Lifespan Observations Database (ID: 1080) |
16293764 |
83 |
OB_000083 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
RPL6B |
Saccharomyces cerevisiae |
851169 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of RPL6B significantly increased replicative life span of BY4741 cells. |
Lifespan Observations Database (ID: 1081) |
16293764 |
84 |
OB_000084 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of TOR1 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that TOR1 and dietary restriction act in the same pathway to promote longevity. |
Lifespan Observations Database (ID: 1082) |
16293764 |
85 |
OB_000085 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Deletion of TOR1 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that TOR1 and dietary restriction act in the same pathway to promote longevity. |
Lifespan Observations Database (ID: 1083) |
16293764 |
86 |
OB_000086 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Deletion of SCH9 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that SCH9 and dietary restriction act in the same pathway to promote longevity. |
Lifespan Observations Database (ID: 1086) |
16293764 |
87 |
OB_000087 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of SCH9 significantly increased replicative life span of BY4742 cells but does not further increase life span when combined with dietary restriction (0.05% glucose). These data support the model that SCH9 and dietary restriction act in the same pathway to promote longevity. |
Lifespan Observations Database (ID: 1087) |
16293764 |
88 |
OB_000088 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. |
Lifespan Observations Database (ID: 1088) |
16293764 |
89 |
OB_000089 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. |
Lifespan Observations Database (ID: 1089) |
16293764 |
90 |
OB_000090 |
2 |
Drosophila melanogaster |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
MSRA |
Drosophila melanogaster |
|
over-expression |
- |
unknown |
unknown |
|
|
|
Flies engineered to overexpress methionine sulfoxide reductase A (MSRA) have a median lifespan up to 70% longer than parental controls that don''t overexpress the protein. Other phenotypes: Flies that overexpress MSRA retain reproductive capacity longer than parental controls that don''t overexpress the protein, and are more active, as measured by a climbing assay. |
Lifespan Observations Database (ID: 108) |
11867705 |
91 |
OB_000091 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of TOR1 increases life span additively with deletion of FOB1. These data support the model that TOR1 and FOB1 act in different pathways to promote longevity. |
Lifespan Observations Database (ID: 1090) |
16293764 |
92 |
OB_000092 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Deletion of TOR or SCH9 increase life span additively with deletion of FOB1 but not with dietary restriction. These data support the model that TOR, SCH9 and dietary restriction act in a single pathway that is distinct from the pathway that FOB1 acts in. Deletion of FOB1 is believed to increase replicative life span by reducing the accumulation of extrachromosomal rDNA circles (ERCs) in the mother cell [10207108]. |
Lifespan Observations Database (ID: 1091) |
16293764 |
93 |
OB_000093 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [ 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [ 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. |
Lifespan Observations Database (ID: 1092) |
16293764 |
94 |
OB_000094 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [ 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [ 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. |
Lifespan Observations Database (ID: 1093) |
16293764 |
95 |
OB_000095 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
FOB1 |
Saccharomyces cerevisiae |
851688 |
deletion / null |
- |
unknown |
unknown |
SCH9 |
Saccharomyces cerevisiae |
856612 |
deletion / null |
- |
unknown |
unknown |
SIR2 |
Saccharomyces cerevisiae |
851520 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of TOR or SCH9 increase life span of sir2 fob1 double mutant cells. SIR2 and FOB1 are believed to act in a single genetic pathway to promote replicative life span by reducing the accumulation of extrachromosomal rDNA circles in the mother cell [ 10521401]. Since dietary restriction also increases the life span of sir2 fob1 double mutant cells [ 15328540], this supports the model that TOR1, SCH9, and dietary restriction act in a single pathway that is distinct from SIR2, FOB1, and extrachromosomal rDNA circles. |
Lifespan Observations Database (ID: 1094) |
16293764 |
96 |
OB_000096 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
TOR1 |
Saccharomyces cerevisiae |
853529 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of TOR significantly increases the replicative life span of PSY316 mother cells. |
Lifespan Observations Database (ID: 1095) |
16293764 |
97 |
OB_000097 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CIT2 |
Saccharomyces cerevisiae |
850361 |
over-expression |
- |
unknown |
unknown |
|
|
|
. Overexpression of CIT2 has no effect on life-span. Other phenotypes: Deletion of CIT2 has no effect on life-span [ 10224252]. CIT2 is not required for the strain specific life-span extension in petite cells. Overexpression of CIT2 has no effect on life-span [ 10224252]. CIT2 is transcribed up to 30-fold higher in petite cells relative to grande cells [ 1986232]. |
Lifespan Observations Database (ID: 109) |
10224252 |
98 |
OB_000098 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
PHB1 |
Saccharomyces cerevisiae |
853033 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of PHB1 results in approximately 20% shorter lifespan. Other phenotypes: Deletion of both PHB1 and PHB2 results in a life span that is approximately 40% shorter than wild type. Phenotypic changes characteristic of aging cells may suggest that PHB1/PHB2 mutants undergo premature aging, not simply reduction in viability. These changes include lengthening of cell cycle and characteristic morphological changes [ 9259555]. No reduction in stress resistance or bulk growth rate. A strong defect in mitochondrial potential was detected in the phb1 phb2 double mutant, and a slight defect in the phb1 single mutant. Deletion of PHB1 is synthetically lethal [ 9259555]. |
Lifespan Observations Database (ID: 10) |
9259555 |
99 |
OB_000099 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CYT1 |
Saccharomyces cerevisiae |
854231 |
deletion / null |
- |
unknown |
unknown |
|
|
Other Ageing Factor Name |
Additional Information |
Dietary restriction |
0.05% glucose |
|
Deletion of CYT1 does not significantly influence replicative life span in the PSY316AUT strain background. Dietary restriction still increases the life span of CYT1 deletion mutants, demonstrating that mitochondrial respiration is not required for life span extension from dietary restriction in yeast. |
Lifespan Observations Database (ID: 1107) |
16311627 |
100 |
OB_000100 |
2 |
Saccharomyces cerevisiae |
Gene Symbol |
Species |
NCBI Gene ID |
Allele Type |
Allele Name |
Reference Allele Type |
Allele Change |
CYT1 |
Saccharomyces cerevisiae |
854231 |
deletion / null |
- |
unknown |
unknown |
|
|
|
Deletion of CYT1 does not significantly influence replicative life span in the PSY316AUT strain background. Dietary restriction still increases the life span of CYT1 deletion mutants, demonstrating that mitochondrial respiration is not required for life span extension from dietary restriction in yeast. |
Lifespan Observations Database (ID: 1109) |
16311627 |